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Once phosphorylated on tyrosine residues, IRS-1 acts as a docking protein for several effector molecules possessing Src homology 2 domains, including p85, the regulatory subunit of PI-3 kinase (PI-3K)
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Octreotide-induced drinking, vasopressin, and pressure responses: role of central angiotensin and ACh
Combined with the concurrent upregulation of dimethylargininase, which degrades an inhibitor of nitric oxide synthase, has been associated with augmented neovascularization, and was overexpressed 1.5-fold (p=0.002) in semaglutide-treated animals, this constitutes substantial evidence of the relevance of the nitric oxide biosynthetic pathway to an account of the cardiac effects of semaglutide
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